University of Calgary researcher Dr. Jeff Dunn is interviewed about new technology developed by the university to detect and monitor concussions. (Jeff McIntosh/The Canadian Press)

Scientists use MRIs to curb use of rats, mice in medical research

Researchers use a small MRI to test possible treatments for cancer, strokes and multiple sclerosis

Medical scientists at the University of Calgary have taken steps to minimize the impact on mice and rats used in their experiments.

The university’s Cumming School of Medicine is outfitted with a small MRI that researchers use as they test possible treatments for cancer, strokes and multiple sclerosis.

“It’s one of the premier ones in Canada,” said Jeff Dunn, director of the school’s Experimental Imaging Centre.

“Anything under 500 grams fits in there, so mostly rats and mice. We use those in medical research obviously for preclinical assessment, how the disease progresses and possibly even more importantly if the treatment is functional.”

The MRI has been in use since 2004. The lab is also equipped with a blood gas analyzer, so tests can be done using blood samples taken from the animals in much the same way they are collected from human patients.

It’s a far cry from when scientists would use rats and mice and have to dissect them at every test stage.

“It really reduces the use of animals in research because, for a time-course study of treatment, we don’t have to do a whole bunch of animals,” Dunn said.

“You can take a small number and follow them over months to see how the treatment is working.”

READ MORE: Animal rights group appeals B.C. court decision over euthanized bear cub

Any research facility receiving government funding is subject to rules set out by the Canadian Council on Animal Care.

Spokeswoman Sandra MacInnis says the organization wants to ensure animal-based science in Canada takes place only when necessary and that the animals receive optimal care.

“For example, when selecting a research model, they must first consider all possible alternatives to animal models, such as computer or cell-culture models,” she wrote in an email.

The executive director of the Vancouver-based Animals in Science Policy Institute says efforts by the University of Calgary and others to use the equipment are a matter of debate.

Elisabeth Ormandy, a former researcher, said putting a mouse under an MRI scanner requires sedation or anesthesia and could be considered a source of distress for an animal since it could happen several times.

“It depends on our own personal ethics,” Ormandy said. “For people who care about that one individual mouse, that (MRI) might still not be OK.”

But she said some people might argue “it’s better to cause a little bit more suffering to one mouse instead of moderate suffering to 10 mice.”

An animal rights organization said there’s no need to use animals in tests at all when computer modelling can be just as useful.

“All things else being equal, certainly hurting and killing fewer animals is better than hurting and killing more animals,” said Jeremy Beckham, research associate with People for the Ethical Treatment of Animals.

But he said that loses the bigger question a little bit.

“There’s not any real basis to think they feel pain any less than, say, a dog or a cat,” Beckham said.

“We’ve bred dogs and cats to be our companions, so we’ve got a little bit more of an emotional attachment to them. But the ethical issues of using rats and mice are staring us in the face just as strongly.”

Bill Graveland, The Canadian Press

Like us on Facebook and follow us on Twitter.

Just Posted

Highlights and winners from the Binche Fishing Derby

The third annual event was a massive succes

Buy BC relaunches to keep business local

Local farmers’ markets may benefit

Province expands program to keep youth away from gang life

The Government of British Columbia is providing $1.12 million in additional funding… Continue reading

Applications for high-speed internet in rural communities being accepted

According to a news release that was issued by the Ministry of… Continue reading

France doubles up Croatia 4-2 to win World Cup

Played in Moscow Russia, latest Fifa World Cup marks the highest scoring final since 1966

Trudeau asks transport minister to tackle Greyhound’s western pullout

Prime Minister Justin Trudeau says he’s asked Transport Minister Marc Garneau to find solutions in Greyhound Canada’s absence.

Hub for mental health and addictions treatment opens at B.C. hospital

St. Paul’s Hospital HUB is an acute medical unit that includes 10 patient beds

Restaurant Brands International to review policy over poaching employees

One of Canada’s largest fast-food company to review ‘no-poach’ franchise agreements

Calgary family’s vacation ends in tragedy on Texas highway

Three people died and four others were injured in the crash

Union construction cost competitive, B.C. Building Trades say

Non-union firms can bid on infrastructure, but employees have to join international unions

Trudeau to shuffle cabinet ahead of Liberals’ team for 2019

Trudeau could lighten the work loads of cabinet ministers who currently oversee more than one portfolio

Car calls 911 on possible impaired B.C. driver

A luxury car automatically calls Princeton police to scene of crash involving alcohol

BC Games marks 40 years in 2018

Cowichan Games a milestone for BC Games Society

VIDEO: Life’s a beach at this B.C. sand sculpting contest

More than $50,000 was up for grabs at the annual contest held in Parksville

Most Read