University of Calgary researcher Dr. Jeff Dunn is interviewed about new technology developed by the university to detect and monitor concussions. (Jeff McIntosh/The Canadian Press)

Scientists use MRIs to curb use of rats, mice in medical research

Researchers use a small MRI to test possible treatments for cancer, strokes and multiple sclerosis

Medical scientists at the University of Calgary have taken steps to minimize the impact on mice and rats used in their experiments.

The university’s Cumming School of Medicine is outfitted with a small MRI that researchers use as they test possible treatments for cancer, strokes and multiple sclerosis.

“It’s one of the premier ones in Canada,” said Jeff Dunn, director of the school’s Experimental Imaging Centre.

“Anything under 500 grams fits in there, so mostly rats and mice. We use those in medical research obviously for preclinical assessment, how the disease progresses and possibly even more importantly if the treatment is functional.”

The MRI has been in use since 2004. The lab is also equipped with a blood gas analyzer, so tests can be done using blood samples taken from the animals in much the same way they are collected from human patients.

It’s a far cry from when scientists would use rats and mice and have to dissect them at every test stage.

“It really reduces the use of animals in research because, for a time-course study of treatment, we don’t have to do a whole bunch of animals,” Dunn said.

“You can take a small number and follow them over months to see how the treatment is working.”

READ MORE: Animal rights group appeals B.C. court decision over euthanized bear cub

Any research facility receiving government funding is subject to rules set out by the Canadian Council on Animal Care.

Spokeswoman Sandra MacInnis says the organization wants to ensure animal-based science in Canada takes place only when necessary and that the animals receive optimal care.

“For example, when selecting a research model, they must first consider all possible alternatives to animal models, such as computer or cell-culture models,” she wrote in an email.

The executive director of the Vancouver-based Animals in Science Policy Institute says efforts by the University of Calgary and others to use the equipment are a matter of debate.

Elisabeth Ormandy, a former researcher, said putting a mouse under an MRI scanner requires sedation or anesthesia and could be considered a source of distress for an animal since it could happen several times.

“It depends on our own personal ethics,” Ormandy said. “For people who care about that one individual mouse, that (MRI) might still not be OK.”

But she said some people might argue “it’s better to cause a little bit more suffering to one mouse instead of moderate suffering to 10 mice.”

An animal rights organization said there’s no need to use animals in tests at all when computer modelling can be just as useful.

“All things else being equal, certainly hurting and killing fewer animals is better than hurting and killing more animals,” said Jeremy Beckham, research associate with People for the Ethical Treatment of Animals.

But he said that loses the bigger question a little bit.

“There’s not any real basis to think they feel pain any less than, say, a dog or a cat,” Beckham said.

“We’ve bred dogs and cats to be our companions, so we’ve got a little bit more of an emotional attachment to them. But the ethical issues of using rats and mice are staring us in the face just as strongly.”

Bill Graveland, The Canadian Press

Like us on Facebook and follow us on Twitter.

Just Posted

It’s time to say “I see you”

Chief speaks out on First Nations issues

Nak’azdli Whut’en a vital part of Fort St. James

Progressive and self sufficient, the First Nation looks to the future

Here’s what Fort St. James councillors refused to hear

Citizens express frustration and anger

Citizens ejected from Municipal Hall – Locked out

Mayor refuses to allow discussion on controversial Bylaw regarding marijuana

Toronto van attack suspect faces 10 counts of first-degree murder

The suspect in the Toronto van attack that killed 10 people and injured 15 others on Monday is a 25-year-old man named Alek Minassian

How to keep local news visible in your Facebook feed

Facebook has changed the news feed to emphasize personal connections. You might see less news.

Doctor sees healing power in psychedelic plant as Peru investigates death of B.C. man

Peru’s attorney general has ordered the arrest of two suspects in the killing of 41-year-old Sebastian Woodroffe

Toronto police officer ‘gave himself the space and time’ in van attack

Footage shows officer standing up, turning off his siren and talking clearly to the suspect

$1.18 to $1.58 a litre: Are you paying the most for gas in B.C.?

Gas prices across B.C. vary, with lowest in Vernon and highest in – you guessed it – Metro Vancouver

Inquest set 10 years after B.C. woman shot, left to die

Lisa Dudley, and her partner, Guthrie McKay were shot in their Mission home in September 2008

B.C. hockey team to retire Humboldt Bronco victim’s number

BCHL’s Surrey Eagles to retire Jaxon Joseph’s No. 10 in light of bus tragedy

B.C. Hells Angels invited to rally by anti-SOGI organizer

The Culture Guard group has helped Hells Angels in the past, said its executive director.

B.C. bill aims to keep Indigenous kids in communities, out of care

Changes to Child, Family and Community Service Act could connect MCFD, Indigenous communities

Most Read